Epic Boss/Season 2

Chapter 1 Mission 4 - Doctor Octopus

 * Location:
 * Deploy Requirements: Black Knight, Psylocke & Union Jack
 * Team-Up: Captain Britain (Optional)
 * Epic Drop: Barber's Razor, Stropped Razor (Challenge Mode)
 * Waves: 1
 * Wave 1: SC-Beta, Doctor Octopus & SC-Beta
 * Strategy: At one point of the battle (usually in his first turn), Doctor Octopus will use a highly damaging move called "Hero Dissecation". Use some powerful healing item after that move (I recommend Shawarma or Gold Nugget) and then, attack. The SC-Beta shouldn't be such a problem. But still, bring your most powerful Bruiser, an Infiltrator and a Generalist for an easier win. Bringing a Blaster is not recommended, as Doctor Octopus is a Tactitian.
 * Total Energy Cost:

Chapter 1 Mission 6 (Premium) - M.O.D.O.K.

 * Location:
 * Deploy Requirements: Scarlet Witch, Spider-Woman & Rogue
 * Team-Up: Gambit (Optional)
 * Epic Drop: Bel Nemeton, Glas Tann (Challenge Mode)
 * Waves: 3
 * Wave 1: Fire Chief, Fire Chief & Fire Chief
 * Wave 2: Director, Director & Director
 * Wave 3: Scientist, M.O.D.O.K. & Scientist
 * Strategy: The first two waves aren't really hard and passing them should not be a problem. On the last wave, a Tactitian could really come in handy, because M.O.D.O.K. is a Blaster. His Psycho-8 (move that applies Mental Anguish) is the most annoying one. Just watch out for his attacks and you'll be fine.
 * Total Energy Cost: 80 Energy if you defeat the Boss + Mini Boss together.

Chapter 2 Mission 4 - Red Skull

 * Location:
 * Deploy Requirements: Thing, Thundra & Wolverine
 * Team-Up: Hank Pym (Optional)
 * Epic Drop: 500 GW Power Supply, 500 GW Power Supply (Challenge Mode)
 * Waves: 1
 * Wave 1: Chiyome, Red Skull & Chiyome
 * Strategy: Just bring your best infiltrator and scrapper.
 * Total Energy Cost:

Chapter 2 Mission 6 (Premium) - Sugar Man

 * Location:
 * Deploy Requirements: Iron Man, Nightcrawler & Tigra
 * Team-Up: Scarlet Witch (Optional)
 * Epic Drop: Revolt 4, Revolt 5 (Challenge Mode)
 * Waves: 1
 * Wave 1: Hydra Rampart, Sugar Man & Hydra Rampart
 * Strategy: Bring a fast blaster like Human Torch to bring down the Ramparts, then get your best scrapper to pummle Sugar Man.
 * Total Energy Cost:

Chapter 3 Mission 5 - Ultron

 * Location:
 * Deploy Requirements: Beast, Ghost Rider & Ms. Marvel
 * Team-Up: Fantomex (Optional)
 * Epic Drop:  Decelerator Bar, Decelerator Sword (Challenge Mode)
 * Waves: 1
 * Wave 1: Ultron
 * Strategy: None
 * Total Energy Cost:

Chapter 3 Mission 6 (Premium) - Sin

 * Location:
 * Deploy Requirements: Colossus, Daredevil & Invisible Woman
 * Team-Up: Punisher (Optional)
 * Epic Drop: Combat Knife, Tactical Knife (Challenge Mode)
 * Waves: 1
 * Wave 1: Power Armor, Sin & Hydra Vanguard
 * Strategy: None
 * Total Energy Cost:

Chapter 4 Mission 3 - Destroyer

 * Location:
 * Deploy Requirements: Emma Frost, Hercules & Thor
 * Team-Up: Valkyrie
 * Epic Drop: Asgardian Gauntlet, Tempered Asgardian Gauntlet (Challenge Mode)
 * Waves: 1
 * Wave 1: Destroyer
 * Strategy: Just bring your best Blasters (Havok is probably the best for this guy), just use Lost Pages of Vishanti if you are inflicted with Cursed Mirror.
 * Total Energy Cost:

Chapter 4 Mission 6 (Premium) - Venom

 * Location:
 * Deploy Requirements: Hank Pym, Ms. Marvel & Wasp
 * Team-Up: Black Panther
 * Epic Drop: Incinerator Unit, High Capacity Incinerator Unit (Challenge Mode)
 * Waves: 1
 * Wave 1: Venom
 * Strategy: Another lone bruiser, either you bring Pym to complement Panther and rip Venom apart or just bring your best blaster.
 * Total Energy Cost:

Chapter 5 Mission 5 - Enchantress

 * Location:
 * Deploy Requirements: Vision, Fandral & Quicksilver
 * Team-Up: Thor (Optional)
 * Epic Drop: Huldran's Call, Huldran's Powerful Call (Challenge Mode)
 * Waves: 1
 * Wave 1: Enchantress, Dark Elf Cannoneer & Jotun Ice-Shaper
 * Strategy:
 * Total Energy Cost:

Chapter 5 Mission 6 (Premium) - Man-Ape

 * Location:
 * Deploy Requirements: Punisher, Havok & Hulk
 * Team-Up: Hercules
 * Epic Drop: Wakandan Rungu, Hardened Wakandan Rungu (Challenge Mode)
 * Waves: 3
 * Wave 1: Hydra Pyro,Hydra Vanguard & Hydra Pyro
 * Wave 2: Hunter, Hunter & Warrior
 * Wave 3: Man-Ape
 * Strategy:
 * Total Energy Cost:

Chapter 6 Mission 3 - Green Goblin

 * Location:
 * Deploy Requirements: Black Knight, Captain Britain and Fantomex
 * Team-Up: Iron Fist
 * Epic Drop: Goblin Mask, Terrifying Goblin Mask (Challenge Mode)
 * Waves:
 * Wave 1: Hellfire Hunter, Green Goblin & Hellfire Commander
 * Strategy:
 * Total Energy Cost:

Chapter 6 Mission 6 (Premium) - Savin

 * Location:
 * Deploy Requirements: Ares, Black Widow and Punisher
 * Team-Up: Deadpool
 * Epic Drop: Laprov, Laprov! (Challenge Mode)
 * Waves: 1
 * Wave 1: Savin
 * Strategy:
 * Total Energy Cost:

Chapter 7 Mission 2 - Mysterio

 * Location:
 * Deploy Requirements: Fandral, Hogun and Mockingbird
 * Team-Up: Daredevil
 * Epic Drop: Mysterium Mirror, Mysterium Manifold (Challenge Mode)
 * Waves: 2
 * Wave 1: Maggia Hitman and Maggia Assassin
 * Wave 2: Maggia Hitman, Mysterio & Maggia Captain
 * Strategy:
 * Total Energy Cost:

Chapter 7 Mission 6 (Premium) - Skadi

 * Location:
 * Deploy Requirements: Agent Venom, Spiral and X-23
 * Team-Up: Any heroes
 * Epic Drop: Brannhammer, Brannblodhammer (Challenge Mode)
 * Waves: 1
 * Wave 1: Onna Bugeisha Skadi & Onna Bugeisha
 * Strategy:
 * Total Energy Cost:

Chapter 8 Mission 4 - Dormammu

 * Location:
 * Deploy Requirements: Doctor Voodoo & Ghost Rider
 * Team-Up: Dr. Strange
 * Epic Drop: Ring of Ikkon, Ring of Valtorr (Challenge Mode)
 * Waves: 2
 * Wave 1: Mindless One, Mindless One and Mindless One
 * Wave 2: Mindless One, Dormammu and Mindless One
 * Strategy: Dormammu is a Generalist with the Passive Ability Relentless, so trying to stun is useless. Just take your most powerful weapons for your Agent and your most powerful hero to fight him.
 * Don't bring heroes using psychic attack and try to use a hero that is immune to burning, chilled etc because Mindless Ones can deal high damage with the stare effect. To kill Dormammu, use classes that counter each other because Dormammu can change class.
 * Additionally, since Dormammu has a new passive: Absorb Energy, do not hit him too much of energy or fire attacks to prevent gaining his Fiery Power.
 * Total Energy Cost:

Chapter 8 Mission 6 (Premium) - High Evolutionary

 * Location:
 * Deploy Requirements: Cable, Falcon & Tigra
 * Team-Up: Domino
 * Epic Drop: Gene Extractor, D1S-i5-5P4R7A (Challenge Mode)
 * Waves: 1
 * Wave 1: Skulker, High Evolutionary & Elite
 * Strategy:
 * Total Energy Cost:

Chapter 9 Mission 3 - Nerkkod

 * Location:
 * Deploy Requirements:  Daimon Hellstrom, Phoenix & Thor
 * Team-Up: Psylocke
 * Epic Drop:
 * Waves: 3
 * Wave 1: Onna Bugeisha, Goliath, Onna Bugeisha
 * Wave 2: Marauder, Onna Bugeisha, Goliath
 * Wave 3: Nerkkod, Onna Bugeisha, Goliath
 * Strategy:
 * Total Energy Cost:

Chapter 9 Mission 4 - Arcade

 * Location:
 * Deploy Requirements:  Colossus, Havok & X-23
 * Team-Up: Spider-Man
 * Epic Drop: Extra Points, High Score (Challenge Mode)
 * Waves: 2
 * Wave 1: Robo Cage, Robo Spiral, Robo Shatterstar
 * Wave 2: Arcade, Robo Fist
 * Strategy:
 * Total Energy Cost:

Chapter 10 Mission 2 - Bastion

 * Location:
 * Deploy Requirements: Karolina Dean, Kate Bishop & Sif
 * Team-Up: Quake
 * Epic Drop:
 * Waves: 1
 * Wave 1: Bastion
 * Strategy:

Chapter 10 Mission 6 (Premium) - Mr. Sinister

 * Location:
 * Deploy Requirements:
 * Team-Up:
 * Epic Drop:
 * Waves:
 * Wave 1:
 * Strategy:

Chapter 11 Mission 1 - Mokk

 * Location:
 * Deploy Requirements: Elsa Bloodstone & Quicksilver
 * Team-Up: Captain Britain
 * Epic Drop:
 * Waves: 1
 * Wave 1:
 * Strategy:

Chapter 11 Mission 2 - Man-Ape

 * Location:
 * Deploy Requirements: Angela & Deathlok
 * Team-Up: Black Panther
 * Epic Drop:
 * Waves: 1
 * Wave 1:
 * Strategy:

Chapter 11 Mission 6 (Premium) - Mandarin

 * Location:
 * Deploy Requirements: Quake & Victor Mancha
 * Team-Up:
 * Epic Drop:
 * Waves: 2
 * Wave 1:
 * Strategy: